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News

Oral fluid analyser for forensic toxicology

Thermo Fisher Scientific - (Radiation Monitoring) : 26 August, 2009  (New Product)
The TSQ Quantum GC triple stage quadrupole from Thermo Fisher Scientific provides rapid and reliable high throughput analysis of oral fluid reducing the need for blood and urine samples in the forensic detection of marijuana
Oral fluid analyser for forensic toxicology
Thermo Fisher Scientific has announced the introduction of a new forensic toxicology application that demonstrates the advanced analytical capabilities of its triple stage quadrupole mass spectrometer for monitoring marijuana in oral fluid. The powerful Thermo Scientific TSQ Quantum GC triple stage quadrupole is capable of performing rapid and reliable confirmation and quantitation analyses and achieves excellent quantitative precision and linearity. Entitled 'High-Throughput Confirmation and Quantitation of THC in Oral Fluids Using the TSQ Quantum GC', this new application note is available to download from the Thermo web site.

Oral fluid analysis is becoming an increasingly popular alternative to blood and urine testing for the detection of drugs, such as marijuana. Oral fluid can be collected and monitored without embarrassment, pain, or the extensive training required to draw blood. Since 9-tetrahydrocannabinol (THC), the pharmacologically active compound found in marijuana, is one of the most commonly used illegal drugs, its analysis in oral fluid has become imperative. This analysis can be extremely challenging due to the low concentrations of THC typically found in oral fluid and the low volumes of oral fluid that are generally available for analysis. In addition, the chemical background from the oral fluid matrix can limit the low detection levels required for this analysis. The Thermo Scientific TSQ Quantum GC overcomes these challenges, routinely measuring THC in oral fluid at a 2 ng/mL cutoff level and below with minimal matrix interferences.

Methods were developed for sample preparation, acquisition and analysis for this forensic toxicology assay. Experimental results demonstrate that the analyzer, operated in multiple reaction monitoring (MRM) mode, is both selective and sensitive enough for accurate trace THC measurements in oral fluid. In addition, the TSQ Quantum GC achieves superior quantitative precision, with coefficients of variation (CV) of 6% or less at 0.8 and 2.5 ng/mL and exceptional linearity and accuracy from 0.2 to 20 ng/mL with no significant carryover.

All method development and validation were performed in an extracted oral fluid calibrating matrix, proving the real world capability of the Thermo Scientific TSQ Quantum GC to perform dependable monitoring of trace levels of THC in oral fluid. In addition, Thermo Scientific ToxLab Forms 2.5 software provided automated sample analysis and quantitation and was used for method validation, including assessments of precision and linearity.
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